GuShiio.com Let’s walk into Paramita Venture’s DeSci investment overview, Alpha incubation ideas and future development trends.
Author: Shenchao TechFlow
Let’s first put the time back to a year ago:
Messari released the “Messari Theses 2024” report, which expresses its optimism about Solana, AI + Crypto, and DeSci.
Looking back over the past year, the market has jointly witnessed the rise of the Solana ecosystem and the explosive development of AI + Crypto, which also proves the value of Messari’s annual report as a top encryption research institution.
As for DeSci, DeSci has become the hottest track in November 2024 under the cheers of CZ and Vitalik, two heavyweights in the encryption industry. However, as the AI Agent and Trump Effect continue to grab market attention, the community’s attitude towards DeSci seems to be heading towards polarization.
Skeptics believe that DeSci is a false proposition that attracts community FOMO in a short period of time under celebrity calls.
Staying bulls say: DeSci can effectively bring transparency, democratization and global cooperation in scientific research. It is not only the next outlet in the encrypted world, but also an important force in promoting the development of human science.
In this community debate, we have the honor to meet with Tykoo, investment director of Paramita Venture, investment manager Eva The two guests had an in-depth dialogue.
As a “ideology-driven” investment firm that has been involved in Crypto since 2021, Paramita focuses on promoting innovation in decentralized information, decentralized science and decentralized society to build a more open and secure cyber future.Currently, the DeSci track projects we are familiar with, including Bioprotocol, VitaDAO and other projects, are supported by Paramita Venture.
When the community was curious about why Paramita Venture cultivated its sharp vision to become a popular project investment institution in DeSci, Tykoo said:
Our professional capabilities tend to be laid out in the process. The core of our focus is always what problems the project is solving, rather than simply looking at its research areas. In addition, the project founder is a very important investment judgment criterion, and his ability to judge the market narrative and control the product rhythm are very critical.
Talking about the community’s discussions on DeSci and Paramita Venture’s confidence in the long-term construction of the DeSci track, Eva said frankly:
DeSci is a “scientific research social movement” destined for a long period. Even if it experiences a “small cycle” of fluctuations,”science is Valuable”. Those who truly believe in and invest in it will win more far-reaching value and rewards.
In this issue, let’s follow Tykoo and Eva’s share and walk into Paramita Venture’s DeSci investment panorama, Alpha incubation ideas and future development trends.
Focusing on the four major links of scientific research, enter the Panorama of Paramita DeSci Investment
Shenchao TechFlow: I am very happy to have the opportunity to have an in-depth exchange with you. First of all, please introduce yourself (you can share some past educational experience, track-related professional/entrepreneurial experience, and opportunities to join Paramita Venture, etc.).
Tykoo：
Hello everyone, I am Tykoo. I used to focus on AI and the Web3 track in the Web2 US$2 fund. I am currently an investment manager at Paramita, responsible for investing in decentralized AI and decentralized scientific research tracks. I am very happy to have this opportunity today. Talk to everyone about Desci.
Eva：
Hello I am Eva, who is currently responsible for investing in the DeSci sector at Paramita and the co-founder of AuraSci. The project community is deeply supported by Paramita. Before joining Paramita, I worked in a Layer 2 public chain team and also worked on NFT projects. I am now in the status of All in DeSci, and I hope to communicate more with you.
Deep Trend TechFlow: If you could summarize in one sentence what Paramita Venture is doing or investment philosophy, how would you describe it?
Eva：
Paramita is a “ideology-driven” investment firm focusing on public agreements. We advocate promoting decentralized information, decentralized science and decentralized society innovation to build a more open and secure cyber future by building a deeper consensus between different entities and minimizing Trust-minimization on a single point.
Shenchao TechFlow: Except for the unanimous call of CZ and Vitalik some time ago, most people don’t know much about Desci, so can you please share what are Desci’s advantages compared to traditional scientific research?
Tykoo：
For DeSci, I think if the scientific research process is summarized into four major links:
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Topic selection and Funding
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research collaboration
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Peer Review and Publishing
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IP commercialization
DeSci is committed to trying to use blockchain technology to solve the pain points of traditional scientific research at every aspect.
Topic selection and Funding aspects:
Traditional scientific research is decided by a small number of funders, and the approval cycle is very long. DeSci not only opens a channel for individual investors to participate in funding cutting-edge or niche projects, but also helps researchers raise funds faster and more flexibly. Research funding. In essence, DeSci efficiently answers a very critical question in the field of scientific research:
“Who” decides “what” research is funded.
Research collaboration:
In the collaboration between the public and researchers, the public can contribute not only funds, but any resources to scientific research projects, such as dynamic terminal data, computing/storage resources, etc. brought through hardware/ DNA testing, etc. DeSci Through the confirmation characteristics brought by blockchain technology, it can not only track contributions, but also improve the transparency of resource allocation and encourage contributors.
In collaboration among researchers, traditional scientific research is often caused by limited data sources, computing power and storage resource allocation, which often causes island problems. DeSci can use on-chain records and smart contracts to track contributions, improving resource allocation transparency and cross-institutional collaboration efficiency.
Peer Review Related to publishing:
Under the traditional model, the review cycle is long and there is a lack of incentives. DeSci can use tokens to encourage reviewers to complete the review work quickly and with high quality, while reducing black-box operations and finding a balance between reputation and financial incentives.
IP Commercialization:
As for IP commercialization, you can not only make profits through patent licensing and technology transfer (a 2B model for enterprises), but also use Tokenization or decentralized recommendation mechanisms (similar to “Amway-style” word-of-mouth promotion) to reach out to more ordinary consumers and realize the 2C commercialization method.
This will allow scientific research results to reach the end market more directly, shorten intermediate links, and improve monetization efficiency.
Overall, compared with traditional scientific research, DeSci’s researchWho will determine the research direction, how to allocate resources, and improvereviewerEfficiency and incentives and maximizing scientific research results “More flexible and transparent solutions to these issues are provided.
Of course, there are still many issues that need to be discussed here, such as whether individual investors are a good group to withstand the long-term and high-risk of scientific research investment? Will secondary market fluctuations have a negative impact on scientific research activities? Can Token incentives maintain the rigour and neutrality of academic research? Regarding the scientific research results of cross-agency and cross-border cooperation, how to reasonably allocate the ownership of IP within the legal framework and how to associate it with Tokens, we are actively communicating and discussing these issues with industry builders and proposing solutions.
Deep Trend TechFlow: It is understood that Paramita Venture has already determined a development plan focusing on Desci during its brand upgrade in July 2023. At that time, Desci had not really entered the public eye, so the community was very curious. How do you and your team understand the trend of DeSci and make the final decision?
Eva：
Our team started paying attention to this field four years ago, but the concept of DeSci was not clear at that time, and more people were talking about Open Science.
Our fund partners all come from scientific backgrounds, so they have always attached great importance to the academic IP sector. When we first came into contact with VitaDAO and learned that they were promoting the architecture of IPNFT, we were deeply attracted by this idea and quickly completed the first layout in the DeSci field.
At the same time, we also created and supported the AuraSci community to explore DeSci-related areas more deeply.
Shenchao TechFlow: Can you tell us about the current investment landscape of Paramita Venture? Including key data such as investment projects and achievements?
Tykoo：
As I shared in my previous question, the scientific research process can be roughly summarized into four major links: topic selection and Funding; collaboration;Peer Review and publishing; and IP commercialization.
Paramita Venture’s investment layout revolves around these four major links:
In the topic selection and funding process, Paramita Venture invested in projects including Bioprotocol and BioFoundry;
In the collaboration process, Paramita Venture has invested in projects including Hetu protocol, Hippocrat, Avinasi labs, Data Lake, DeSci World, and BiohackerDAO;
In the Peer Review and Publishing segment, Paramita Venture has invested in projects including ResearchHub;
In terms of IP commercialization, Paramita Venture has invested in projects including Quantum Biology, VitaDAO, AthenaDAO, ValleyDAO, etc.
As can be seen,At present, Paramita Venture’s investment not only includes multiple well-known projects in the DeSci sector, but also covers the complete scientific research process from Funding, collaboration, publishing and commercialization.
From screening criteria to quantification of outcomes: Capturing the next Alpha of DeSci track
Deep Trend TechFlow: From VitaDao, which studies longevity, to ValleyDAO, which focuses on climate change and food security, to Athena, which focuses on women’s health DAO…DeSci is blooming in different segments. Which type of DeSci product does Paramita Venture prefer?
Tykoo：
This question is actually asking another perspective on investment entry, which is based on the research field.But I think our professional capabilities tend to allow us to deploy in the process rather than delve into specific research segments.
Of course, there are many new projects emerging here. In addition to the climate security and food security mentioned in the question, there are also quantum fields and materials fields, including space exploration. This is definitely not what we are best at, but investing in them can be very helpful for us to understand DeSci, understand the industry, and build key links.
So many times, in addition to some early projects other than our investment, we donate as public participants to support ecological development.
Another very noteworthy point is why the Bio field has become a representative sector of the financing process?
This is because venture capital fund raising activities in the fields of biotechnology and life sciences have gradually slowed down after reaching a peak in 2021, and 2024 has become the lowest level since 2019. Crypto is in a bull market, and there is a cyclical problem in between. The mismatch of funds, so the emergence of Bio just solves this problem.
But if the same logic is applied to Space Technology, it may not be true, because there is a large amount of hot money pouring in the space field. The pain points for each segment are different. For example, AI, as a research field, may have more pain points in the data collaboration process, which is also what we tend to support.
Therefore, our core focus is always what problems the project is solving, rather than simply looking at its research area.
Shenchao TechFlow: When selecting specific projects to invest, what dimensions will Paramita Venture evaluate and screen projects?
Tykoo：
In my early years, I developed a very comprehensive project evaluation system, which divided into dozens of dimensions, and then each dimension had its own weight.
But later I found that as the project develops to different stages and under the influence of factors such as different power agencies, these evaluation dimensions, including weights, are actually changing dynamically, and grasping these weights has become one of the most important capabilities.
Especially the longer you stay in the Crypto primary market, the more you find that for early projects, especially early industries like i,The team seems to be the only important indicator: the team’s judgment of the market narrative, control of the product rhythm, and even the ability to turn are all critical.
Some people are just very energetic. For example, Paul, the founder of Bio, is a very energetic person with the ability to unite many people around him.
For example, RSC was founded by Brian Armstrong, and the entire ResearchHub team gives people a feeling of being down-to-earth. Patrick often talks with us about how to let real researchers use their products more to solve their real problems. In addition, we are also promoting the construction of ResearchHub China, and we welcome everyone to understand and communicate.
Deep Trend TechFlow: What infrastructure do you think will be needed to support the DeSci outbreak? How does Paramita Venture plan this?
Tykoo：
First of all, it can be clear thatThe style of our fund has always been to like infrastructure products.
Speaking of this issue, just like the four major links mentioned in the sharing just now, I think the most important infrastructure needs will appear in the second link, which is the collaboration link.
In this link, there are many opportunities for infrastructure in different industries. Of course, we will not follow the logic of infrastructure, middle layer, and application to make DeSci’s investment layout, mainly because this field is really still very early, and not many application layer products have yet come out. Where does the infrastructure demand come from?
Actually,I found that many of the infrastructure in the territory are actually industry-specific, such as storage, data and other fields.Therefore, we look more at specific cases, that is, what practical problems have been solved in their subdivided fields or scientific research processes, and many practical problems are reflected in applications.
There are several real needs that may exist in the scientific research field, such as:
How to link real-world scientific research data and ensure its authenticity? Similar to what the oracle is doing.
How to correspond real-world rights and interests to the chain under the legal framework? Similar to what RWA is doing.
There are more questions, including how to deal with off-chain governance? How to determine the contributions of different researchers? There are also issues such as how to attribute. Regarding this issue, traditional scientific research often uses factors such as the number of journals, journal weight, and number of citations plus a simple algorithm to determine reputation. In our investment landscape, Hetu protocol is trying to solve this problem.
Deep Trend TechFlow: Scientific research results are often difficult to quantify, but as VC Often result-oriented. Faced with this problem, what measures does Paramita Venture take to deal with it?
Tykoo：
This question is particularly good. In fact, many DeSci projects try to quantify the results of scientific research work by introducing market games, because traditional scientific research cannot be awarded corresponding rewards because it is not easy to quantify.
Deep Trend TechFlow: A discussion from the community. There are actually some projects on the track with the concept of “community-driven DeSci Financing Platform”. What do you think are the advantages of Paramita Venture compared with them?
Tykoo：
I think it’s great,The market is free.
If the project party can raise more funds on the open market, why must it accept VC funds? As long as the funds do flow to DeSci projects with the right values, we sometimes even encourage project owners to go to the open market to try the water. We can also support them directly on the open market, which is no problem.
Paramita’s advantages are mainly reflected in the fact that as an institution, we have stronger risk tolerance and can accept longer time periods. We also have stronger asset discovery and risk pricing capabilities, as well as re-pricing capabilities brought by post-investment services.
In addition, when it comes to advantage analysis, I have to mention my excellent colleagues: for example, Eva’s Aurasci scientist community, Frances’s Udaya developer community, Celine’s Moksha Labs incubator, and our partners ‘early selfless and heartless donations to the DeSci community.
These efforts allow us to have some key resources in the DeSci ecosystem in North America and Asia.
From Meme to DeFi, explore the future trend of deep integration of DeSci and Crypto
Deep Trend TechFlow: Pump Science is a blockbuster, and the community has launched a wide-ranging discussion about DeSci and Meme. What do you think of the intersection of these two tracks?
Tykoo：
I think every field has Meme attributes, which have commonalities and individuality.
The common denominator is thatMeme in DeSci is still the exchange and competition of traffic and capital flows in different fields:The story told by Web2 is that Meme brings attention to scientific segments, popularize science, bring in funds, and promote science; what Web3 earns is the transaction volume brought to Meme by the legitimacy of scientists and their backgrounds. If DeSci is regarded as a scam-style fund-raising tool, its credibility may be seriously damaged.
Some friends may lose money because of some Memes positioned on DeSci, and then question the entire track. This is what we as industry builders do not want to see the last thing. I think the main problem with Meme is how to punish evil deeds. It is still a question worth discussing if it needs to be solved through mechanism design.
Personality is thati’s story requires specialization in the subdivision,Usually, when we play Meme, we like to talk about looking for angles. However, due to professional reasons, some people can’t find the right angle for DeSci’s Meme angle, but the positions are already full. This imbalance can easily harm the progress of scientific research.
Of course, in the long run, the market will correct this behavior.
Another personality isThe market will be more tolerant of certain DeSci Memes,To a certain extent, the same logic as buying a sports lottery: if you lose, you will be regarded as a contribution to science.
Deep Trend TechFlow: Although DeSci has a grand vision, as ordinary users, it is weak to perceive it, so market attention will always be attracted by products with intuitive financial income attributes. The crypto economy is also based on the overall DeFi Financial construction. In this regard, do you think the deep integration of DeSci and DeFi will bring more attention to the track?
Tykoo：
Absolutely. Not only the combination of DeSci and DeFi, but even the combination of traditional scientific research and traditional finance will surely bring more attention to scientific research.
As long as scientific research is given certain financial attributes and a speculative market is created for this field, it will definitely attract the participation of profit-seekers.
Deep Trend TechFlow: Admittedly, DeSci’s development is still in its very early stages, which is both an opportunity and a challenge for early planners. What problems do you think exist in the current development of DeSci? How will Paramita Venture respond?
Tykoo：
I think now,i has a problem with managing investor expectations across the field,If the project party intentionally or unintentionally transmits some unclear information, investors will not know what they are buying, so they will not have enough understanding of the investment cycle/risk or even what the corresponding rights and interests are behind it., will hurt the market.
Scientific research requires concentration, and the market needs new news to create emotions, so some more transparent ways of playing, such as live broadcast/prediction markets, may attract more market attention. Such projects are actually not like Scientific research is more like science popularization.
The other is the lack of good supervision and punishment mechanisms for bad market participants.
Moreover, like many RWA / Oracle products, because DeSci involves real-world rights and real-world information flow, these require lower-level agreements to be built together.
Industry trend insight and future route planning
Deep Trend TechFlow: The discussion on DeSci in social media has become seriously polarized. As a leader in the DeSci field,long-term doctrineSoldier, what do you think of the doubts about DeSci in the community? What is it that allows you and your team to pass through FUD Emotional, firmly choose DeSci?
Eva：
The doubts and debates that have appeared on social media actually prove that DeSci, an emerging thing, is being paid attention to and discussed by more and more people. As “long-term fighters” in the DeSci field, we welcome and understand these doubts.
Any social movement that wants to change the traditional system is bound to face different views and even fierce opposition, because this shows that it is impacting the existing order and bringing new possibilities.
The reason why we can still firmly choose DeSci in FUD emotions is mainly based on the following beliefs and observations:
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long-term doctrine: From “small cycle” to “big narrative”
DeSci is a social movement that relies on blockchain and decentralization concepts to reshape the way scientific research funding and collaboration. Compared with traditional scientific systems, this kind of change cannot be completed in a year or two, but requires a long-term narrative and practice.
Judging from our early participation in the DeSci ecosystem, even after experiencing a “small cycle” of fluctuations, we can see its potential for continuous iteration in terms of community, technology and concepts. This common belief in scientific value and decentralization allows us to maintain a long-term perspective rather than just short-term market heat.
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Continuous evolution: the emergence of new ways of play and new integration
This wave has seen more innovative combinations and gameplay, such as the combination of MEME culture and the concept of DeScAI, which combines decentralized open collaboration with AI’s powerful data processing and prediction capabilities.
These new explorations not only broaden DeSci’s application scenarios, but also bring more creativity to future scientific research models. When DeSci’s decentralized features are deeply integrated with cutting-edge technologies of AI, a more disruptive scientific research ecosystem may be formed.
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The value of science itself
Most importantly, we firmly believe that “science is Valuable.”
No matter how market sentiment fluctuates, the value of scientific research will not be shaken. The significance of DeSci is to provide science with a more open, transparent and stimulating soil. If this soil can truly produce breakthrough research results, such as accelerating drug research and development through large-scale data analysis of AI, or using decentralized funding to support more grassroots scientific research projects, then the long-term value of DeSci can be fully verified.
This is a “scientific research social movement” destined for a long period of time and requires time, belief and collective wisdom to cultivate and witness it. Doubt voices can help the DeSci community constantly reflect and iterate, and those who truly believe in and devote themselves to the DeSci ecosystem will win more far-reaching value and rewards in this continuous evolution process.
Deep Trend TechFlow: Last question, welcome to share Paramita Venture’s work priorities in 2025 so that the community can better understand the upcoming milestones.
Eva：
In 2025, Paramita Venture will still focus its energy on the two areas of DeSci and AI, and continue to explore more interesting integrated gameplay.
We hope to consolidate existing investment and research results, drive more interdisciplinary and cross-community collaboration and inject new imagination and creativity into the ecology.
At the same time, we will further improve the post-investment support system for projects, from technical empowerment and funding relay to community co-construction, providing continuous assistance for scientific research and blockchain projects that can truly solve pain points and have long-term value.
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